Research technician

Research technician

Molecular functions and therapeutic potentials of human BAF complexes in acute myeloid leukemia.

Job description

Acute myeloid leukemia (AML) is a type of hematological malignancies that is driven by many different transcription factors. Although the transcription factors are the key oncogenic drivers in AML, these proteins are difficult to be pharmacologically targeted. However, transcription factors always require many co-activators to control oncogenic transcriptional program. These co-activators are often druggable. Among these transcriptional co-activators, human BRG1/BRM associated factor (BAF) complexes play a critical role in many types of cancer including AML, and may also be the important therapeutic targets.

We are looking for a highly motivated research technician who is interested in studying molecular aspects of hematological malignancies. We will combine state-of-the-art gene editing, (epi)genomics, and computational methods to study the molecular functions of the BAF complexes in AML. Furthermore, we will test our anti-BAF therapies in 2D and 3D (primary) culture models. The ultimate goal of our research is to develop novel anti-AML therapeutics for AML treatment.

The initial employment will be one year, with a possible extension for 3 years after a positive evaluation.

Work environment

You will be part of a newly formed research group in the department of hematology at the Erasmus Medical Center in Rotterdam. Currently, the department has several research groups covering different topics of hematology, including basic and (pre-)clinical research in leukemia, myeloma, thrombosis and other blood related diseases. The new research team will focus on molecular aspect of human AML, and closely collaborate with other teams in the department to understand basic and translational questions of this disease.

Qualifications and skills

Requirements:

• You have a BSc/MSc in either (molecular) biology, genetics, or (bio)chemistry.
• Solid experience with molecular biology techniques, mammalian cell culture, and FACS analysis is a requirement;
• You are familiar with gene editing techniques such as CRISPR-CAS9.
• You are team-oriented, highly motivated, self-driven, and proficient in written and spoken English.

Desirable skills:

• You have experience in the relevant fields such as hematology or immunology.
• You are familiar with epigenetic techniques such as ChIP-seq and ATAC-seq.
• You are familiar with human iPSC and/or organoids culture.

Before you apply please check our conditions for employment.

More information

No agencies please.

Application process Step 2 - Selection

Based on your application, we check to see if there is a fit between us. We will let you know as soon as possible whether you are invited for an interview.

Step 3 - Job interview

You have been invited for an interview, great! In this first meeting we get to know each other and see if you can form an idea of the position, the department and Erasmus MC. If the interview goes well usually a second interview follows.

Step 4 - Offer and terms of employment

It's a match! Your future manager will discuss your salary and employment with you. You will also receive more information about our other terms of employment.

Step 5 - Getting started

Your first working day has come! We are more than happy to have you. Your new department will give you a warm welcome and provide you with all the information you need. Enjoy your job at Erasmus MC!

https://www.erasmusmc.nl/